Children’s Oncology Group Study of Late-Occurring Complications from Childhood Cancer

ALTE03N1: Key Adverse Events Following Childhood Cancer

Protocol Description

The goal of this Children’s Oncology Group study is to learn how to identify patients who are at greater risk of developing late-occurring complications from their childhood cancer. Researchers will observe how genetics, cancer treatment, and other factors contribute to developing complications related to heart function, blood circulation, and development of other cancers. Insights from this study may help clinicians improve observation of patients to help prevent such complications from occurring or to identify them sooner.

Eligibility Criteria

This study is enrolling patients, infants through adults, who had a diagnosis of primary cancer at age 21 or younger, irrespective of their current age, with or without a late-occurring complication.
Males and Females: All ages


Researchers will collect medical record information as well as blood and saliva samples for biologic and genetic testing. Participants will complete a questionnaire about family history and health history.
Visits: 1
Duration: Not applicable

Status: Open to Enrollment

Source(s) of Support

Children’s Oncology Group (ALTE03N1)
National Cancer Institute

Primary Investigator

A. Kim Ritchey, MD

Contact Information

For more information about the study, please contact the UPMC Children’s Hospital of Pittsburgh Hematology-Oncology research team, at: