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This Children’s Oncology Group Phase I trial studies the effects of MK-1775 when given with localized radiation therapy in treating young patients with newly diagnosed diffuse intrinsic pontine gliomas (DIPG), a condition for which there is no standard treatment. The drug may help stop tumor cells by blocking some enzymes needed for their growth. Researchers believe use of MK-1775 in combination with radiation may work better than radiation therapy alone.
Study Level: Phase I
Subject to certain exclusion criteria, this study is open to males and females, ages 37 months to 21 years with newly diagnosed DIPG.
Males and Females: Ages 37 months to 21 years
Treatment consists of radiation therapy every weekday for 6 weeks for a total of 30 treatments. MK-1775 will be given as a capsule by mouth following radiation therapy according to dosage level protocols for this study. Blood work and other tests, as well as periodic evaluations will be required at specific intervals. After completing the therapy, participants will be followed by study doctors every 2 to 3 months.
Visits: 30 for radiation treatments
Duration: 6 weeks for therapy, plus extended follow-up
Children’s Oncology Group (Study ADVL1217)
National Cancer Institute, Cancer Therapy Evaluation Program
Study Description at National Institutes of Health
Jean Tersak, MD
For more information about the study or enrollment, please contact:
Research Coordinator Angela Connelly, RN, BSN
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
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