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This research study, initiated by Children’s Hospital of Pittsburgh, is a clinical trial of vaccinations targeted against three proteins found on the majority of childhood ependymoma cells in children with recurrent ependymomas. Ependymomas are among the most common brain and spinal cord tumors in children and those that recur have very few effective treatment options.
Study Level: Pilot
Eligibility criteria includes being between the ages of 12 months and 21 years, having the HLA-A2 tissue type and being willing to travel to Pittsburgh to receive the vaccines. Testing of potential participants is done through a blood test at no charge by the study institution.
Males and Females: Ages 12 months to 21 years
Vaccines will be given by subcutaneous injection at Children’s every 3 weeks for eight times and then every 6 weeks 12 times, depending on response.
Visits: Approximately 20, depending on response to the vaccine
Duration: Up to 2 years
Connor's Cure Fund, UPMC Children's Hospital of PittsburghNational Institutes of Health
Study Description at National Institutes of Health
Cancer and Blood Disorder Research
Alberto Broniscer, MD
Andrew Bukowinski, MD
James Felker, MD
Ian F. Pollack, MD
For more information about the study or enrollment, please contact:
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
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