Children's Hospital is part of the UPMC family.
Be safe anytime, anywhere.
To find a pediatrician or pediatric specialist, please call 412-692-7337 or search our directory.
A resource for our network of referring physicians.
For more information about research, please call our main office at 412-692-6438.
Ranked #8 Nationally by U.S. News & World Report.
Through this Pediatric Brain Tumor Consortium investigation, researchers will study the effects of selumetinib (AZD6244) in treating or re-treating young patients with a low-grade glioma that has come back (recurrent) or does not respond to treatment (refractory). Researchers believe that AZD6244 may stop the growth of tumor cells by blocking some enzymes needed for cell growth.
Study Level: Phase I/II
Subject to certain exclusion criteria, this study is enrolling pediatric patients who have a progressive, recurrent or refractory low-grade glioma or non-optic pathway pilocytic astrocytoma.
Males and Females: Ages 3 to 21 years
Participants in this study will take AZD6244 twice daily in 4-week courses that follow continuously for up to 26 courses. Medical examinations, including blood testing and neurologic assessments will be required at the beginning of each course, and imaging assessments will be done every 3 months.
Visits: Up to 26
Duration: Approximately 2 years
National Cancer Institute
Pediatric Brain Tumor Consortium (PBTC-029B)
Study Description at National Institutes of Health
Cancer and Blood Disorder Research
James Felker, MD
For more information about the study or enrollment, please contact:
Research Coordinator Sharon Dibridge
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
In addition to the main hospital, Children's has many convenient locations in other neighborhoods throughout the greater Pittsburgh region.
With MyCHP, you can request appointments, review test results, and more.
For questions about a hospital bill call:
To pay your bill online, please visit UPMC's online bill payment system.
Interested in giving to Children's Hospital? Support the hospital by making a donation online, joining our Heroes in Healing monthly donor program, or visiting our site to learn about the other ways you can give back.