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This multi-center study organized by the Children’s Oncology Group is designed to find the best dose of selinexor that can safely be given with radiation therapy, and to determine what beneficial and side effects selinexor has on young people with a high-grade glioma or diffuse intrinsic pontine glioma (DIPG).
Subject to certain exclusion criteria, this study is enrolling patients ages 1 through 21 diagnosed with either high-grade glioma or DIPG.
Males and Females: Ages 1 through 21 years
The protocol for this study begins with 8 weeks of chemoradiotherapy, entailing radiation treatments with an oral dose of selinexor given once each week. This will be followed by a 2-week rest period, after which up to 24 cycles of maintenance chemotherapy will begin. Each cycle of maintenance chemotherapy consists of taking selinexor orally once a week for 4 weeks.
Visits: Number of visits will vary based on participant response to protocol.
Duration: The treatment on this study takes a little over 2 years in most cases.
Children’s Oncology Group (ACNS1821)
National Cancer Institute
Study Description at the National Institutes of Health
Cancer and Blood Disorder Research
James Felker, MD
For more information about the study or enrollment, please contact the UPMC Children’s Hospital of Pittsburgh Neuro-Oncology team, at: email@example.com
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
In addition to the main hospital, Children's has many convenient locations in other neighborhoods throughout the greater Pittsburgh region.
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