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The overall goal of this multi-center study by the Children’s Oncology Group is to see if using the drugs dabrafenib and trametinib after radiation treatment is better than prior treatments in helping to eliminate or shrink high-grade gliomas in young people. Dabrafenib works by blocking a protein, called BRAF, that lets cancer cells grow without stopping. Trametinib works similarly by blocking the protein MEK, which allows cancer cells to grow without stopping.
Subject to certain exclusion criteria, this study is enrolling patients ages 1 through 21 years who have been newly diagnosed with a high-grade glioma with a BRAF V600 mutation.
Males and Females: Ages 1 through 21 years
The treatment on this study is divided into 2 phases of therapy, which is done following surgery to remove the tumor. The first phase is radiation treatment, which lasts 6 to 7 weeks in most cases. After a 4-week rest period, the maintenance phase begins, with up to 24 cycles of chemotherapy using dabrafenib and trametinib provided in tablet, capsule, or liquid form. Each cycle lasts 28 days.
Visits: Number of visits will vary based on participant response to protocol.
Duration: A little more than 2 years in most cases.
Children’s Oncology Group (ACNS1723)
National Cancer Institute
Study Description at the National Institutes of Health
Cancer and Blood Disorder Research
James Felker, MD
For more information about the study or enrollment, please contact the UPMC Children’s Hospital of Pittsburgh Neuro-Oncology team, at: email@example.com
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
In addition to the main hospital, Children's has many convenient locations in other neighborhoods throughout the greater Pittsburgh region.
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