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This multicenter trial by the Children’s Oncology Group trial studies different chemotherapy and radiation therapy regimens to compare how well they work in treating young patients with newly diagnosed, previously untreated, high-risk medulloblastoma. In particular, investigators will be examining whether carboplatin in combination with radiation is more effective on tumor cells than radiation alone.
Subject to certain exclusion criteria, this study is open to patients of both genders ages 3 to 21, who have been diagnosed as having M0 medulloblastoma, M+ medulloblastoma or diffusely anaplastic medulloblastoma.
Males and Females: Ages 3 to 21
There are two arms to the study. Arm A is standard chemoradiotherapy and maintenance therapy; Arm B adds carboplatin to the chemoradiotherapy. The chemoradiotherapy portion of each arm is 6 weeks followed by a 6-week rest period. The maintenance and continuation stages comprise 6, 28-day cycles.
Visits: Same number as required with standard therapy
Duration: Approximately 9 to15 months depending on study arm
Children’s Oncology Group (ACNS0322)
National Cancer Institute
Study Description at National Institutes of Health
Jean Tersak, MD
For more information about the study or enrollment, please contact:
Research Coordinator Angela Connelly, RN, BSN
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
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