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This Children’s Oncology Group Phase III trial is studying different chemotherapy and radiation therapy regimens to compare how well they work in treating young patients with newly diagnosed, previously untreated, high-risk medulloblastoma or supratentorial primitive neuroectodermal tumor (PNET). More specifically, it will determine whether radiation therapy and carboplatin together are more effective than radiation therapy alone, and whether isotretinoin can improve treatment outcomes.
Subject to certain exclusion criteria, the study is open to individuals of both genders, from age 3 to 21, who have been diagnosed with medulloblastoma or supratentorial PNET.
Males: Ages 3 to 21 years
Females: Ages 3 to 21 years
There are 4 treatment groups into which participants will be randomly assigned. Treatment begins within 31 days of tumor removal. For the first 6 weeks, all groups will receive radiation therapy plus the anti-cancer drug vincristine, which is the standard treatment. For the 6-month maintenance chemotherapy stage that follows, 2 of the groups will also receive carboplatin. One of the carboplatin groups and one of the standard care groups will also receive maintenance and additional continuation therapy with a chemotherapy regigmin that will include isotretinoin.
Frequency of visits: 5 days a week for the initial cycle; follow-up cycles vary
Duration: Approximately 9 to 15 months, depending on which treatment arm participant is assigned
Children’s Oncology Group (Study ACNS0332)
National Cancer Institute
Study Description at National Institutes of Health
Cancer and Blood Disorder Research
James Felker, MD
For more information about the study or enrollment, please contact:
Angela Connelly, RN, BSN
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
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