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This multicenter trial by the Children’s Oncology Group, studies a combination of two drugs in treating patients with newly diagnosed acute promyelocytic leukemia (APL). Tretinoin may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth, and arsenic trioxide may stop cancer cell growth by either killing the cells, by stopping them from dividing, or by stopping them from spreading. Researchers believe that these may provide a beneficial alternative to current standard chemotherapy for these conditions, which involves high doses of anthracyclines, which can have long-term side effects, especially to the heart.
Patients who have been newly diagnosed with APL up to age 21 and of either gender may be considered for this study, subject to certain exclusion criteria.
Males and Females: Up to 21 years of age
Patients enrolled in the study will be placed into a study group of either standard-risk or high-risk cases, as determined by blood tests. Participants will receive tretinoin and arsenic trioxide as part of their chemotherapy, and those in the high-risk group will also receive idarubicin and dexamethasone during the first stage of chemotherapy, which is induction therapy.
Visits: About the same as required by standard chemotherapy for these conditions.
Duration: 8 to 9 months
Children’s Oncology Group (AAML1331)
National Cancer Institute
Study Description at National Institutes of Health
Leukemia Overview and Causes
Cancer and Blood Disorder Research
A. Kim Ritchey, MD
For more information about the study or enrollment, please contact:
A. Kim Ritchey, MD
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
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