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This multicenter trial by the Children’s Oncology Group studies different combinations of risk-adapted chemotherapy regimens and their side effects, comparing how well they work in treating younger patients with newly diagnosed standard-risk B acute lymphoblastic leukemia (B-ALL) or patients with B-lineage lymphoblastic lymphoma (B-LLy) that is found only in the tissue or organ where it began (localized).
Subject to certain exclusion criteria, this study is open to males and females, ages 1 to 10 years, who have newly diagnosed B-ALL and are already enrolled in COG AALL08B1, or patients with B-LLy ages 1 to 30.
Males and Females: Ages 1 to 30 years
Study participants will receive standard “induction” chemotherapy at the initial stage of this study followed by testing to determine their risk level. Participants with high-risk conditions will be assigned to one of four maintenance therapy treatment groups, each which takes the same combination of five drugs administered over 12-week courses, but with dosage levels for specific drugs calibrated at different levels as specified in the protocol. Participants with low-risk conditions will be randomly assigned to one of two treatment arms, each with a different chemotherapy regimen. Courses cycles repeat for to 2 to 3 years.
Visits: Varies from daily to weekly to monthly depending on the treatment arm and stage of treatment.
Duration: 2 to 3 years for therapy, with patients followed for up to 10 years from the time of enrollment.
Children’s Oncology Group (AALL0932)
National Cancer Institute
Kim Ritchey, MD
For more information about the study or enrollment, please contact:
Research Coordinator Angela Connelly, RN, BSN
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
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