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This Phase I and II Children’s Oncology Group trial is studying the drug PF-02341066 in treating patients with relapsed or refractory solid tumors, central nervous system (CNS) tumors, neuroblastoma, anaplastic large cell lymphoma (ALCL) and anaplastic lymphoma kinase (ALK) fusion proteins, mutations or amplification. In the lab, PF-02341066 has demonstrated an ability to inhibit the proteins c-MET and ALK, both of which are believed to be important to the growth of cancer cells. Through this study, researchers are studying the side effects and effectiveness of PF-02341066.
Subject to certain exclusion criteria, the study is open to individuals of both genders, ages 1 to 21, who have been diagnosed with a malignant solid tumor, CNS tumor, neuroblastoma, ALCL or an ALK condition that is resistant to treatment by any standard therapy.
Males: Ages 1 to 21 years
Females: Ages 1 to 21 years
Treatment consists of up to 24, 28-day cycles in which participants receive twice-a-day doses of PF-02341066. Blood tests will also be done. Specific sampling requirements and dosages are determined by the participant’s specific condition and in which arm of the study he or she is enrolled.
Frequency of visits: weekly for therapy and tests
Duration: Up to 2 years
Children’s Oncology Group (Study ADVL0912)
National Cancer Institute
Study Description at National Institutes of Health
For more information about the study or enrollment, please contact:
Angela Connelly, RN, BSN
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
In addition to the main hospital, Children's has many convenient locations in other neighborhoods throughout the greater Pittsburgh region.
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