Children's Hospital is part of the UPMC family.
Be safe anytime, anywhere.
To find a pediatrician or pediatric specialist, please call 412-692-7337 or search our directory.
A resource for our network of referring physicians.
For more information about research, please call our main office at 412-692-6438.
Ranked #6 Nationally by U.S. News & World Report.
Patient-Centered Comprehensive Medication Adherence Management System to Improve Effectiveness of Disease Modifying Therapy with Hydroxyurea in Patients with Sickle Cell Disease
Through this study researchers will determine whether an interactive medication management program will help children and adults with sickle cell disease who are taking hydroxyurea (HU) for their condition. HU is the only disease-modifying therapy for SCD, and can be effective in reducing complications such as pain crisis and acute chest syndrome, and improving survival. It is, however, vastly underutilized and poorly adhered to for a variety of reasons. Through this study, structured interventions will be individualized to patient barriers and preferences, and will consist of improved access to care through virtual clinic visits and in-home testing, adherence management via video-based, directly observed therapy (Mobile-DOT), and patient support using text and telephone follow-up.
Subject to certain exclusion criteria, the study is accepting participants of both genders between the ages of 2 and 65 who have sickle cell disease and are receiving HU therapy.
Males: 2 to 65 years old
Females: 2 to 65 years old
Participants will be placed into one of two study groups. Both will receive standard clinical care, and one will also receive interventions aimed at improving their adherence to the medication regimen. The intervention group receives reminders to take medications and a combination of other interventions, such as interviews, Mobile-DOT, clinic visits every 3 months, surveys, and medical and pharmacy record review. Through Mobile-DOT, participants use a mobile device to make a video of themselves consuming the medication and then send the recording to researchers.
Duration: 2 years
Patient-Centered Outcomes Research Institute (PCORI)
Study Description at PCORI
Cancer and Blood Disorder Research
Gregory Kato, MD
For information about the study or enrollment, please contact:
Study Coordinator Angela Martino, BSN, RN
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
In addition to the main hospital, Children's has many convenient locations in other neighborhoods throughout the greater Pittsburgh region.
With myCHP, you can request appointments, review test results, and more.
For questions about a hospital bill call:
To pay your bill online, please visit UPMC's online bill payment system.
Interested in giving to Children's Hospital? Support the hospital by making a donation online, joining our Heroes in Healing monthly donor program, or visiting our site to learn about the other ways you can give back.