Tumors/Sarcoma Clinical Studies

Some of the many Cancer and Blood Disorders research opportunities available related to sarcomas, including bone tumors and certain soft tissue tumors, are listed below. Select a study to review a brief description and requirements. Parents or guardians of children who might be eligible are encouraged to inquire about enrollment. Contact information is provided at the end of each study.

Please note that Pilot and Phase I studies are the most experimental and should be considered only after other treatments or trials have been attempted without success.

Thank you for exploring these opportunities and helping us to find cures and prevent childhood disease.

Clinical Studies


Children’s Oncology Group Long-Term Follow-up of Study Participants

ALTE05N1: Umbrella Long-Term Follow-Up Protocol for Participants with and without a History of Cancer

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Children’s Oncology Group’s Project: EveryChild

APEC14B1: Project:Every Child, A Registry, Eligibility Screening, Biology and Outcome Study

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Ewing Sarcoma Tissue Banking Study

AEWS07B1: A Children’s Oncology Group Protocol for Collecting and Banking Ewing Sarcoma Specimens

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Ewing Sarcoma Treatment with Combination Chemotherapy Including Topotecan – Phase III

AEWS1031: Adding Vincristine-topotecan-cyclophosphamide to Standard Chemotherapy in Initial Treatment of Non-metastatic Ewing Sarcoma

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Fitness Program for Adolescent and Young Adult Childhood Cancer Survivors: The StepByStep Study – Phase III

ALTE2031: StepByStep: A Trial of a Mobile Health and Social Media Physical Activity Intervention Among Adolescent and Young Adult Childhood Cancer Survivors

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Fitness Program for Children and Adolescents Following Cancer Therapy – Phase III

ALTE1631: A Web-based Physical Activity Intervention among Children and Adolescents

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M0 Medulloblastoma Treatment in Very Young Children – Phase I

ADVL1314: Study of Eribulin Mesylate, a Novel Microtubule Targeting Chemotherapeutic Agent, in Children with Refractory or Recurrent Solid Tumors including Lymphomas

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Osteosarcoma Tissue Banking Study

AOST06B1: A Children’s Oncology Group Protocol for Collecting and Banking Osteosarcoma Specimens

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Pediatric Tumors and Specimen Study

ACNS02B3: A Children’s Oncology Group Protocol for Collecting and Banking Pediatric Specimens Including Rare Pediatric Tumors

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Solid Tumor and Leukemia Treatment with Larotrectinib – Phase II

ADVL1823: Larotrectinib for Previously Untreated TRK Fusion Pediatric Solid Tumors and TRK Fusion Relapsed Pediatric Acute Leukemias

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Solid Tumor and Lymphoma Treatment with PI3K – Phase I/II

ADVL1721: Study of PI3K Inhibitor Copanlisib in Pediatric Patients with Relapsed/Refractory Solid Tumors or Lymphoma

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Solid Tumor Maintenance Protocol – Phase II

AflacST1903: A Maintenance Protocol of Sirolimus in Combination with Metronomic Chemotherapy in Children with High-Risk Solid Tumors

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Solid Tumor Treatment with Palbociclib – Phase I

ADVL1921: Study to Evaluate the Safety and Pharmacokinetics of Palbociclib (IBRANCE®) in Combination with Irinotecan and Temozolomide in Pediatric Patients with Recurrent or Refractory Solid Tumors

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