Children's Hospital is part of the UPMC family.
Be safe anytime, anywhere.
To find a pediatrician or pediatric specialist, please call 412-692-7337 or search our directory.
A resource for our network of referring physicians.
For more information about research, please call our main office at 412-692-6438.
Ranked #8 Nationally by U.S. News & World Report.
This multicenter research study, explores how well dinutuximab works when given with sargramostim (GM-CSF) in treating patients with osteosarcoma that has come back after treatment. Dinutuximab is a type of drug called a monoclonal antibody. It is designed to recognize a specific target on the surface of cancer cells. It then attaches to the cancer cells and kills them, without harming normal cells. Sargramostim may help the body increase the production of white blood cells, which help to fight off infections. Giving sargramostim with dinutuximab may help the dinutuximab work better and kill more cancer cells.
Subject to certain exclusion criteria, this study is open to pediatric patients of both genders, up to 29 years of age, who have osteosarcoma with at least one episode of disease recurrence in the lungs, and which was surgically removed at least 4 weeks prior to study enrollment.
Males and Females: Up to 29 years old
Participants will receive the study drugs in 28-day cycles. Sargramostim will be given on days 1 through 14 via injection, and dinutuximab via intravenous infusion on days 4 and 5 of each cycle. After 2 treatment cycles, tests and imaging will be done to see if the tumor has come back. If not, patients may remain enrolled in the study for up to 5 cycles.
Visits: Same as standard chemotherapy for this condition
Duration: About 5 months
Children’s Oncology Group (AOST1421)
National Cancer Institute
Study Description at National Institutes of Health
Jean Tersak, MD
For more information about the study or enrollment, please contact:
Jean Tersak, MD
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
In addition to the main hospital, Children's has many convenient locations in other neighborhoods throughout the greater Pittsburgh region.
With myCHP, you can request appointments, review test results, and more.
For questions about a hospital bill call:
To pay your bill online, please visit UPMC's online bill payment system.
Interested in giving to Children's Hospital? Visit Children's Hospital of Pittsburgh Foundation's website to make a donation online.