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The PAZNTIS multicenter trial by the Children’s Oncology Group studies how well pazopanib hydrochloride, combination chemotherapy, and radiation therapy work in treating young patients with newly diagnosed non-rhabdomyosarcoma soft tissue sarcomas (NRSTS). In adults with certain NRSTS, pazopanib has been shown to have anti-tumor effects.
Subject to certain exclusion criteria, this study is open to pediatric patients of both genders, age 2 or greater, who have been newly diagnosed with an intermediate- or high-risk NRSTS that could not be removed by surgery at the time of diagnosis.
Males and Females: Ages 2 years and up
For this study, participants will receive oral doses of pazopanib along with standard chemotherapy for the 12-week induction phase. If the tumor has responded to therapy, it will be removed by surgery and the patient will advance to the 9-week continuation phase, during which the study drug will continue to be provided with chemotherapy, possibly supported by radiation therapy and additional surgery.
Visits: Same number as required for standard chemotherapy
Duration: About 6 months
Children’s Oncology Group (ARST1321)
National Cancer Institute
Study Description at National Institutes of Health
Jean Tersak, MD
For more information about the study or enrollment, please contact:
Jean Tersak, MD
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
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