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Through this multi-center Children’s Oncology Group study, researchers are investigating the potential of eribulin mesylate for treatment of certain cancers in children and adolescents. Specifically researchers will evaluate eribulin mesylate used in treatment of rhabdomyosarcoma (RMS), non-rhabdomyosarcoma soft tissue sarcoma (NRSTS) and Ewing sarcoma (EWS) that has either come back or is not responding to treatment.
Subject to certain exclusion criteria, this study is enrolling pediatric patients who have been diagnosed with relapsed or refractory RMS, NRSTS and EWS.
Boys and Girls: 1 through 17 years of age
In 21-day cycles, study participants will receive a specified dose of eribulin mesylate intravenously on days 1 and 8. Additional testing, including blood work and physical examinations, will be done during study visits. Participants can remain in the study unless their condition worsens or side effects are determined to be harmful. Participants will continue to be followed by the study team for up to 1 year after stopping the study medication.
Visits: On days 1 and 8 of each treatment cycle
Duration: Open-ended, providing participants are tolerating the drug, have improved or stable disease, and that it is in their best interest to continue
Children’s Oncology Group (ADVL1722)
Study Description at the National Institutes of Health
Cancer and Blood Disorder Research
Children’s Oncology Group CureSearch
Ewing Sarcoma Overview and Causes
Andrew Bukowinski, MD
For more information about the study or enrollment, please contact:
Sharon Dibridge, Clinical Research Coordinator
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
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