Your health can’t wait. Learn how we’re making our facilities safer and schedule your care now.
Children's Hospital is part of the UPMC family.
Be safe anytime, anywhere.
To find a pediatrician or pediatric specialist, please call 412-692-7337 or search our directory.
A resource for our network of referring physicians.
For more information about research, please call our main office at 412-692-6438.
Ranked #8 Nationally by U.S. News & World Report.
Through this multi-center Children’s Oncology Group study, researchers are evaluating the effects of the drug XL184 (cabozantinib) given to patients suffering from certain types of cancers that have returned or did not respond to standard treatments. These cancers include: rhabdomyosarcoma, non-rhabdomyosarcoma soft tissue sarcomas, osteosarcoma, Wilms tumor or other rare tumor, such as medullary thyroid carcinoma, renal cell carcinoma, hepatocellular carcinoma, hepatoblastoma, adrenocortical carcinoma, and other solid tumors including central nervous system tumors. XL184 is a small-molecule inhibitor and has been shown to reduce tumor growth and tumor blood vessel growth in laboratory research and some adult clinical studies.
Subject to certain exclusion criteria, this study is accepting patients, ages 2 to 30 years, with one of the cancers listed in the description above, either recurrent or refractory, or newly diagnosed with no known curative therapy.
Males and Females: Ages 2 to 30 years
In 4-week cycles, participants will take the study drug orally on a daily basis. Evaluations, including tests and imaging, will be done after the first 2 cycles. Participants may remain in the study for additional cycles and evaluations as long as their tumors are not getting larger or coming back, and side effects are not too severe.
Visits: Evaluations will be done after cycles 2, 4 and 6, and every third cycle thereafter.
Duration: Open-ended while the study remains active
Children’s Oncology Group (ADVL1622)
National Cancer Institute
Study Description at National Institutes of Health
Cancer and Blood Disorder Research
Jean Tersak, MD
For more information about the study or enrollment, please contact:
Andrew Bukowinski, MD, MS
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
In addition to the main hospital, Children's has many convenient locations in other neighborhoods throughout the greater Pittsburgh region.
With myCHP, you can request appointments, review test results, and more.
For questions about a hospital bill call:
To pay your bill online, please visit UPMC's online bill payment system.
Interested in giving to Children's Hospital? Support the hospital by making a donation online, joining our Heroes in Healing monthly donor program, or visiting our site to learn about the other ways you can give back.