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The purpose of this multi-center interventional study is to evaluate the efficacy of oseltamivir, also known by the trade name Tamiflu, for the treatment of influenza (flu) in transplant recipients. Researchers are investigating whether a higher dose of the study drug than what is conventionally given can lead to faster resolution of flu in this patient group, whose immune systems are compromised by immunosuppressant treatment.
Subject to certain exclusion criteria, this study is open to transplant recipients (liver, kidney, liver and kidney, allogenic haematopoietic stem cell transplant), who are 1 year of age and older who are shown to be positive for flu by a rapid diagnostic test at baseline. Males: Age 1 and older Females: Age 1 and older
Following initial screening examination, participants will be randomly divided into groups that will be given the study drug in either a conventional dose (based on age and weight) or a high dose. Blood testing and other examinations will be conducted during follow up visits. Visits: Up to 6 Duration: 1 month
Hoffmann-La Roche
Study description at National Institutes of Health
Marian G. Michaels, MD, MPH
For information, or to enroll, please contact: Marian G. Michaels, MD, MPH 412-692-7438 Noreen Jeffrey, RN 412-692-6786
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh One Children’s Hospital Way 4401 Penn Ave. Pittsburgh, PA 15224
In addition to the main hospital, Children's has many convenient locations in other neighborhoods throughout the greater Pittsburgh region.
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