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This research study is taking a look at a new combination of medicines used in liver transplantation to see how they work to prevent rejection. Traditional combinations of tacrolimus plus steroids can cause suppression of the function of lymphocytes, delayed growth and development of bones. In this study, both the traditional combination and the introduction of thymoglobulin used with tacrolimus in place of steroids will be used.
Eligible candidates will include males and females, under 21 years of age, who are about to receive a liver transplant.
Males: 21 years and younger
Females: 21 years and younger
Participants will undergo various routine procedures for transplant patients, including blood draws, while receiving either the newer combination or the traditional combination of anti-rejection drugs throughout the study duration.
Visits: Multiple, as with conventional post-transplant care
Duration: 1 year
National Institutes of Health
Pediatric Transplantation Department, Children’s Hospital of Pittsburgh of UPMC
Rakesh Sindhi, MD
For more information, please contact:
Katie Hindes Kalata, BS, MPH
Kym Smith, BS
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UPMC Children’s Hospital of Pittsburgh
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
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