Nephrology Clinical Studies

Some of the clinical trial programs being conducted by researchers in the Division of Pediatric Nephrology are shown here. Select a study to review a brief description and requirements. Parents or guardians of children who may be eligible for certain studies are encouraged to inquire about enrollment. Contact information is provided at the end of each description.

Thank you for exploring these opportunities and helping us to find cures and prevent childhood disease.

Clinical Studies


Chronic Kidney Disease & Hyperkalemia Treatment with Patiromer: The EMERALD Study – Phase II

Study to Evaluate the Pharmacodynamic Effects, Safety, and Tolerability of Patiromer for Oral Suspension in Children and Adolescents 2 to

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Chronic Kidney Disease & Hyperparathyroidism Treatment with Hectorol – Phase III

Study to Assess the Safety and Efficacy of Hectorol® (doxercalciferol capsules) in Pediatric Patients with Chronic Kidney Disease Stages 3 and 4 with Secondary Hyperparathyroidism Not Yet on Dialysis

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FSGS & the Effects of LDL Apheresis

Effect of LDL-Apheresis on Cardiovascular and Renal Outcomes in Focal Segmental Glomerulosclerosis

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FSGS and Identification of the APOL1 Genetic Mutation

A Study of the Prevalence of Apolipoprotein L1 (APOL1) Alleles Among Individuals With Proteinuric Kidney Disease Who Are of Recent African Ancestry or Geographic Origin

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FSGS Therapy Using Sparsentan – Phase III

The Effects of Sparsentan, a Dual Endothelin Receptor and Angiotensin Receptor Blocker, on Renal Outcomes in Patients with Primary Focal Segmental Glomerulosclerosis

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FSGS Treatment with VX-147 – Phase IIa

A 2-Part Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of VX‐147 in Adults with APOL1-mediated Focal Segmental Glomerulosclerosis

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Hyperoxaluria Treatment with DCR-PHXC – Phase II

Study to Evaluate the Efficacy, Safety, and Tolerability of DCR-PHXC Solution for Injection in Patients with Primary Hyperoxaluria

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Kidney Transplant Rejection Study Using Novel Blood Test

Utilization of dd-cfDNA to Assess for Rejection

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