Your health can’t wait. Learn how we’re making our facilities safer and schedule your care now.
Children's Hospital is part of the UPMC family.
Be safe anytime, anywhere.
To find a pediatrician or pediatric specialist, please call 412-692-7337 or search our directory.
A resource for our network of referring physicians.
For more information about research, please call our main office at 412-692-6438.
Ranked #9 Nationally by U.S. News & World Report.
In this multi-center international study, researchers are evaluating the drug sparsentan to see if it is effective in lowering the amount of protein in urine caused by primary focal segmental glomerulosclerosis (FSGS), a rare disease affecting the kidneys. FSGS causes scarring in parts of the kidney that filter waste materials from blood, allowing protein to leak into the urine, a condition called proteinuria. If the protein leaks for too long, it can lead to kidney failure. The study compares the effects of sparsentan to irbesartan, a drug that is used to treat adults with proteinuria.
Subject to certain exclusion criteria, this study is accepting participants, ages 8 and older, who have FSGS.
Males and Females: Ages 8 through adult
Following a screening period of up to 6 weeks, participants will be randomly assigned to take either sparsentan or irbesartan in capsule form. The treatment period is 108 weeks during which time they will return to the study center for 14 visits for examinations, blood and urine sampling, and to complete quality of life questionnaires. There will be additional visits at the end of treatment and for follow-up.
Visits: Up to 17
Duration: 2 years, 6 months
Study Description at National Institutes of Health
Michael Moritz, MD
For more information about the study or enrollment, please contact:
Vibha Chauhan, PhD, CCRP, CCRC
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
In addition to the main hospital, Children's has many convenient locations in other neighborhoods throughout the greater Pittsburgh region.
With myCHP, you can request appointments, review test results, and more.
For questions about a hospital bill call:
To pay your bill online, please visit UPMC's online bill payment system.
Interested in giving to Children's Hospital? Support the hospital by making a donation online, joining our Heroes in Healing monthly donor program, or visiting our site to learn about the other ways you can give back.