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The purpose of this study is to assess the effectiveness and side effects of the drug lorcaserin for people who have Dravet syndrome, a rare form of epilepsy that develops in infancy and causes convulsive seizures.
Subject to certain inclusion and exclusion criteria, this study is enrolling participants who are at least 2 years of age and who have been diagnosed with epilepsy with Dravet syndrome.
Males and Females: Ages 2 and older
Following a four-week screening period, participants will be randomly assigned to a group that will take either lorcaserin or a placebo over a period of 14 weeks. Upon completion of this core phase, participants may participate in a 12-week extension period in which all participants will receive the study drug. From screening through treatment phases and final follow-up, participants will be seen by the study team at regular visits for physical examinations and medical testing. After the extension phase, participants may also be able to join an extended-access program to continue taking lorcaserin.
Duration: 34 weeks
Study Description at National Institutes of Health
Yoshimi Sogawa, MD
For more information about the study or enrollment, please contact:
Clinical Research Coordinator Dawn Thomas RN, MSN, CPN
412-692-5142 or 412-864-7442
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UPMC Children’s Hospital of Pittsburgh
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
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