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The purpose of this research study is to identify immune markers and genes that can be used to determine which babies are at risk for the development of necrotizing enterocolitis (NEC), the death of intestinal tissue. NEC is a serious abdominal infection that requires treatment with antibiotics and sometimes surgery. Even with these treatments, infants with NEC have an increased risk of dying, or if they survive, having longer hospital stays and problems with feeding than babies who do not develop abdominal infections.
The study is accepting infants who have developed signs of NEC as well as otherwise healthy infants of the same age for comparative purposes.
Males and Females: Newborns, both premature and full-term
Blood samples and other biologic samples, such as urine and stool, will be collected as part of normal newborn care. Samples will be processed in the lab to search for genomic expression, genomic methylation, and other immune system markers.
Visits: None beyond normal clinical care
Duration: Not applicable
Newborn Medicine Research
Liza Konnikova, MD
For more information about the study or enrollment, please contact:
Spenser Shaffer, CRN
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
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