Necrotizing Enterocolitis Risk Assessment

Identifying Infants who are at High Risk for Necrotizing Enterocolitis

Protocol Description

The purpose of this research study is to identify immune markers and genes that can be used to determine which babies are at risk for the development of necrotizing enterocolitis (NEC), the death of intestinal tissue. NEC is a serious abdominal infection that requires treatment with antibiotics and sometimes surgery. Even with these treatments, infants with NEC have an increased risk of dying, or if they survive, having longer hospital stays and problems with feeding than babies who do not develop abdominal infections.

Eligibility Criteria

The study is accepting infants who have developed signs of NEC as well as otherwise healthy infants of the same age for comparative purposes.
Males and Females: Newborns, both premature and full-term

Requirements

Blood samples and other biologic samples, such as urine and stool, will be collected as part of normal newborn care. Samples will be processed in the lab to search for genomic expression, genomic methylation, and other immune system markers.
Visits: None beyond normal clinical care
Duration: Not applicable

Status: Open to Enrollment

Primary Investigator

Liza Konnikova, MD

Contact Information

For more information about the study or enrollment, please contact:
Spenser Shaffer, CRN
412-692-7750