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The objectives of this study are to determine whether high stress leads to reduced response to common treatments for asthma, such as inhaled corticosteroids and short-acting bronchodilators, and to then identify the genetic and epigenetic mechanisms for treatment resistance. Asthma is the most common chronic disease among children, and Puerto Ricans have the highest burden from asthma of all people in the United States.
Subject to certain exclusion criteria, this study is open to Puerto Rican children of both genders, ages 9 to 14 years, who have a confirmed diagnosis of mild to moderate persistent asthma. Boys and Girls: Ages 9 to 14 years
Study visits will take place at the Medical Science Campus of the University of Puerto Rico in San Juan. The initial screening visit will include a physical examination and respiratory testing, as well as a questionnaire to help researchers assess the child’s level of stress. Follow-up visits for testing, including blood work and additional surveys, will be done at weeks 1, 3 and 7. At the second visit (week 1), participants will be given an inhaled medication for treatment of asthma and instruction in daily use. Visits: 4 Duration: 7 to 8 weeks
National Heart, Lung, and Blood Institute University of Pittsburgh University of Puerto Rico
Study Description at National Institutes of Health Pediatric Asthma Center at Children’s Hospital of Pittsburgh of UMPC Facts About Asthma Pulmonary Medicine, Allergy and Immunology Research
At Children’s Hospital of Pittsburgh of UPMC Juan C. Celedón, MD, DrPH
At the University of Puerto Rico Glorisa Canino, PhD
For more information about the study or enrollment, please contact:
At Children’s Hospital of Pittsburgh of UPMC Liz Hartigan, Research Coordinator 412-692-7060
At the Medical Science Campus of the University of Puerto Rico Sonia Delgado, Study Coordinator, or Edna Acosta-Perez, Co-Investigator 787-758-2525, Ext. 2129
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UPMC Children’s Hospital of Pittsburgh One Children’s Hospital Way 4401 Penn Ave. Pittsburgh, PA 15224
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