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The purpose of this CHEC-SC study is to test the amount of salt in the sweat of cystic fibrosis patients to find out how different people respond to treatment with CFTR modulator therapy and to see if CFTR therapy impacts long- term health outcomes. Researchers know that some cystic fibrosis patients have different reductions in sweat chloride after treatment with CFTR modulator therapy, but they do not know why or whether the sweat chloride value achieved after such treatment impacts long-term health outcomes.
Subject to certain exclusion criteria, this study is open to participants of both genders, ages 4 months and older, who have cystic fibrosis and are being treated with a CFTR modulator, which targets the cystic fibrosis transmembrane conductance regulator (CTFR) gene. Males and females: Ages 4 months and older
This study requires a single visit for a physical examination and testing, including spirometry and a sweat chloride test. Visits: 1 Duration: Not applicable
Cystic Fibrosis Foundation Therapeutics
Study Description at National Institutes of Health Cystic Fibrosis Pulmonary Medicine Research
Joseph Pilewski, MD
For more information about the study or enrollment, please contact: Clinical Research Nurse Coordinator Rose Lanzo BS, RRT, CRC 412-692-5872
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh One Children’s Hospital Way 4401 Penn Ave. Pittsburgh, PA 15224
In addition to the main hospital, Children's has many convenient locations in other neighborhoods throughout the greater Pittsburgh region.
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