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The purpose of this CHEC-SC study is to test the amount of salt in the sweat of cystic fibrosis patients to find out how different people respond to treatment with CFTR modulator therapy and to see if CFTR therapy impacts long- term health outcomes. Researchers know that some cystic fibrosis patients have different reductions in sweat chloride after treatment with CFTR modulator therapy, but they do not know why or whether the sweat chloride value achieved after such treatment impacts long-term health outcomes.
Subject to certain exclusion criteria, this study is open to participants of both genders, ages 4 months and older, who have cystic fibrosis and are being treated with a CFTR modulator, which targets the cystic fibrosis transmembrane conductance regulator (CTFR) gene.
Males and females: Ages 4 months and older
This study requires a single visit for a physical examination and testing, including spirometry and a sweat chloride test.
Duration: Not applicable
Cystic Fibrosis Foundation Therapeutics
Study Description at National Institutes of Health
Pulmonary Medicine Research
Joseph Pilewski, MD
For more information about the study or enrollment, please contact:
Clinical Research Nurse Coordinator
Rose Lanzo BS, RRT, CRC
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
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