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The purpose of this multi-center collaborative research study is to help determine the length of time that a person with cystic fibrosis should be given antibiotics intravenously (via IV) for treatment of pulmonary exacerbations. A pulmonary exacerbation is a worsening of respiratory symptoms. Doctors and patients want to make sure the patient gets antibiotics long enough to get better without treating too long and exposing the patient to unnecessary risks.
Subject to certain exclusion criteria, this study is open to participants of both genders, ages 18 and older, who have cystic fibrosis and are going to be put onto IV antibiotics for a pulmonary exacerbation.
Males and females: Ages 18 and older
In this study, participants will be given standard-of-care IV antibiotics. For patients who meet criteria for early robust response within the first week of treatment, IV antibiotics will be provided for a total of either 10 or 14 days, determined by randomization. For patients who do not meet the criteria for early robust response to treatment, IV antibiotics will be provided for a total of either 14 or 21 days, again determined by randomization. Physical exams, tests and blood and sputum samples will be collected at certain intervals.
Duration: 24 to 35 days
Medical University of South Carolina
Cystic Fibrosis Foundation Therapeutics
CF Therapeutics Development Network Coordinating Center
University of Washington
Study Description at National Institutes of Health
Pulmonary Medicine Research
Joseph Pilewski, MD
For more information about the study or enrollment, please contact:
Clinical Research Nurse Coordinator
Rose Lanzo BS, RRT, CRC
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
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