Genetic Relationships Between Parents and Transplant Recipients

Transmissible Genetic Traits in Transplant Outcomes

Protocol Description

This study is examining whether transplant outcomes are influenced by certain changes in transplant recipients’ genes. Genes contain the information necessary to control activities of a cell, including the accurate production of proteins, which are necessary for all types of cell function. By measuring the structure of genes within the cells of a parent or sibling of a transplant recipient, and comparing it with the structure of genes within the recipient, researchers hope to be able to detect changes that will help them understand why different people with organ transplants have different outcomes after transplantation. This information may also help in tailoring the best anti-rejection treatment for each person.

Eligibility Criteria

Parents or siblings of patients who have received a transplant of the liver, intestine, kidney, pancreas, heart or lung, alone or in combination, are eligible for participation in the study.
Males: Ages 18 and older
Females: Ages 18 and older


A small blood and/or saliva sample will be collected at the time consent is provided for participation in the study.
Visits: 1
Duration: Not applicable

Status: Open for Enrollment

Source(s) of Support

Pediatric Transplantation Department, Children’s Hospital of Pittsburgh of UPMC

Primary Investigator

Rakesh Sindhi, MD

Contact Information

For more information, please contact:
Katie Hindes Kalata, BS, MPH
Kym Smith, BS