Read the Latest
Children's Hospital is part of the UPMC family.
Be safe anytime, anywhere.
To find a pediatrician or pediatric specialist, please call 412-692-7337 or search our directory.
A resource for our network of referring physicians.
For more information about research, please call our main office at 412-692-6438.
Ranked #6 Nationally by U.S. News & World Report.
This Phase I clinical trial is being done to evaluate the safety and feasibility of a treatment for type 1 diabetes in which dendritic cells (a type of white blood cell) are removed from study participants, modified in the laboratory and re-injected into the participants. In mice it has been shown that this type of diabetes-suppressive cell vaccine successfully inhibits the interaction and destructive effect of “T cells” (lymphocytes) on the insulin-producing cells of the pancreas. If this study proves that the treatment is safe, more studies will be done to see if treated dendritic cells will protect insulin-producing cells.
Subject to certain exclusion criteria, the study is open to men and women, ages 18 to 35, who have been diagnosed as having type 1 diabetes for at least 5 years and who are in good health with no diabetes complications.
Males: ages 18 to 35
Females: ages 18 to 35
Participants will have dendritic cells (a type of white cell) removed from the blood in a 2- to 4-hour hospital procedure. For about half of the study participants, dendritic cells will be modified with substances that may enable them to inhibit the destruction of insulin-producing cells in the subjects. The dendritic cells of the remaining participants will not be treated. For the following 6 weeks, the dendritic cells of study participants will be injected back into them subcutaneously, with no need for anesthesia. All subjects will be monitored for side effects over a 12-month period.
Duration: 1 year
University of Pittsburgh
Study Description at National Institutes of Health
Article in Science Daily
Nick Giannoukakis, PhD
Theresa Whiteside, PhD
Silva Arslanian, MD
To get started, please contact:
Brian Copeman, BA CRTT
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
In addition to the main hospital, Children's has many convenient locations in other neighborhoods throughout the greater Pittsburgh region.
With myCHP, you can request appointments, review test results, and more.
For questions about a hospital bill call:
To pay your bill online, please visit UPMC's online bill payment system.
Interested in giving to Children's Hospital? Support the hospital by making a donation online, joining our Heroes in Healing monthly donor program, or visiting our site to learn about the other ways you can give back.