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The TEDDY study - The Environmental Determinants of Diabetes in the Young - is a worldwide study involving over 7,000 eligible children. The TEDDY study is a 2-part study where newborns are initially screened to determine whether they possess higher risk genes that predispose juvenile diabetes or type 1 diabetes mellitus (T1DM). Research has shown that children who get diabetes have certain kinds of high-risk genes; however, not all children who are higher risk get diabetes. Upon determining the presence of these genes in participants, the long-term goal of the TEDDY study will be the identification of infectious agents, dietary factors or other environmental causes, including psychosocial factors that trigger T1DM in genetically susceptible individuals.
Approximately 36 children are being followed at Children’s Hospital of Pittsburgh of UPMC. Enrolled in this study are those with the highest risk for the development of diabetes; particularly with a biological parent or sibling with insulin-dependent diabetes. Participants will be followed until they turn 15 or develop T1DM.
Boys: Infants up to 4 months
Girls: Infants up to 4 months
Blood sampling and a genetic screen determined eligibility due to higher risk genes called HLA genes. Throughout the length of the study, various samples are being collected at each visit. Parents maintain a record of their child’s diet and life experiences. If a participant develops autoantibodies, an oral glucose tolerance test will be administered every 6 months to determine whether the participant is developing diabetes.
Duration: 15 years
National Institutes of Health
National Institute of Diabetes and Digestive and Kidney Diseases
National Institute of Allergy and Infectious Diseases
National Institute of Child Health and Human Development
National Institute of Environmental Health Sciences
Juvenile Diabetes Research Foundation
Centers for Disease Control and Prevention
Study Description at National Institutes of Health
Dorothy J. Becker, MBBCh
For information, please contact:
Margaret A. Franciscus, RN
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
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